The USB port has been starting to take over the duties of RS-232 for the last few years.
You should seriously consider USB as an interface for your project.
Oh, yes; that might seem like a ludicrously obvious statement -- "duh! nobody's been using Serial for a decade now".
Not so easy: there is a lot more than mice and printers out there.
RS-232 has been the preferred interface for custom-build devices, scientific instruments, and low-production devices far long after everybody started using USB for mice and high volume consumer devices.
My most direct experience comes from amateur astronomy and accessibility computer accessories for the visually-impaired. Until not too long ago, all of the above were still mainly RS232 devices, and a common headache has been finding a way to plug those in a modern laptop. RS232-to-USB consumer adapted will sometimes work, sometimes not. At least one manufacturer of accessibility devices (a braille embosser) has stated to us that they don't recommend RS232-to-USB adapters because they have had (unspecified) problems with them.
I don't know the cause. Maybe USB components are more expensive, maybe it's the need to interface with legacy devices that would be expensive to redesign; maybe it's what the engineers know. Maybe it's just "ain't broken, don't fix it" or simple inertia.
It's only been in the last couple of years, but I've finally seen a number of these devices offered with USB ports instead of serial RS232; in some cases, RS-232 versions have been discontinued. It's just taking a little longer.