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From : http://technet.microsoft.com/en-us/library/cc288905.aspx?ppud=4

Do not use “/*” to indicate wildcard managed sites at the root of the site collection. Using this wildcard prevents a site being created at the root of the Web application. Many SharePoint features rely on having a site collection at the root of the Web application, and if this is missing, these features will not work correctly. For example, Explorer View will not work for a document library.

I'm wondering what problems may occur if there is no site collection at the root of a web application.

A: 

If Microsoft state that problems will occur then don't do it. Regardless of possible errors, the web application will not be supported by Microsoft. If things go wrong you won't be able to get help. IMHO this makes it not worth even considering.

Alex Angas