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VB.NET ClickOnce failure

I built my application in VB.NET and tried to use the publish feature in VS2008. I uploaded it to my webserver and cannot get the darn thing to work! No matter the client and no matter which method I choose (Publish to cd/dvd or webserver), I always get this error. I can, after some labor, get the application to run by itself, however.

http://pastebin.com/m5ff87e8c

Any help at all is appreciated.

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