Setuptools lets you list requirements for optional features
# mypackage
'extras_require' : { 'PDF' : ['reportlab'], 'DOCX' : ['docxlib'] }
and another package can specify 'requires' : [ 'mypackage[PDF]' ].
If another package wants to require more than one extra from the first package, can it ask for 'requires' : [ 'mypackage[PDF, DOCX]' ]?
from: http://peak.telecommunity.com/DevCenter/setuptools#declaring-dependencies
setuptools and pkg_resources use a common syntax for specifying a project's required dependencies. This syntax consists of a project's PyPI name, optionally followed by a comma-separated list of "extras" in square brackets, optionally followed by a comma-separated list of version specifiers
...so your answer is yes