I have a computer that won't let me enable direct3d acceleration (i've tried almost everything).
So I need a 2d engine in c# that supports openGL.
I found Axiom3D, but I can't run the samples and I can't build the project, and it's driving me crazy. When I try to run the samples, it just blits open the command prompt and closes right away.
You might try OpenTK. It's a lightweight wrapper around OpenGL for .NET. As far as C API wrappers go, it's a pleasure to use in .NET.
I share your frustration with Axiom3D. It seems great, but getting the thing running is a helluva lot of effort. Also there seem to be three different branches to choose from, just to add to the confusion.
If you have a computer that won't enable 3d acceleration via Direct3D there's a good chance that it won't support OpenGL either - or at best only support it in software rendering mode.
If the Axiom3D samples open a a command prompt and then fail closing the window try opening a command prompt first, then running the sample from that:
cd C:\axiom3d\samples <-- or where ever it's actually installed
sample1.exe <-- or what ever it's actually called
This should show you the output and leave the window open, giving you the opportunity to read it. You could also redirect the output to a log file for future reference.