You can't compare them like that. Or at least, you shouldn't. Each one uses the memory in a different way. This is especially true if you're tunning your DB's for performance.
MyISAM has specific buffers for indexes and it uses the OS disk buffer for caching other data. It doesn't make sense to have your buffers larger than the sum of your indexes, but the more memory you give it, the faster it will be.
InnoDB has a buffer pool for all data. You configure this based on your available memory and how much you want to give it. InnoDB buffers as much of your data in memory as possible. If you can fit the entire DB in memory, InnoDB will never read from disk. A lot of InnoDB databases see huge performance hits when the data size becomes larger than the buffer pool.
MySQL is very configurable. It's tunable to meet your needs. Typically, databases should be given as much memory as possible since they are almost always disk bound. More memory means more can be buffered.