This error means your trying to give a value (or a read only object) a value.
If summedPopularity.getItemAt(z) is the only thing accepting anything,try changing that to a var
var someVariable:Number =0;
for (var z:int=0; z<this.tags.getItemAt(i).yearPopularity.length; z++) {
someVariable = summedPopularity.getItemAt(z) + tags.getItemAt(i).yearPopularity.getItemAt(z);
}
I think this would work fine,
thus denoting summedPopularity.getItemAt(z)
is an object type.
trace(summedPopularity.getItemAt(z)); //<<< Debug stop and inspect
Try that, aside from that, you'll have to give us more code and show us what summedPopularity is.
Hope it helps.