You have some datas like this. Encrypt your data with these codes, and store it in appSettings. When u call them to use, decrypt to use.
<add key="SmtpServerHost" value="blablablabla" />
<add key="SmtpServerPost" value="25" />
<add key="SmtpServerUserName" value="blablablabla" />
<add key="SmtpServerPassword" value="blablablabla" />
then make a class library TripleDES.cs for ex.
and this is how to encrypt or decrypt your Appsetting values
public class TripleDes
{
    readonly byte[] _key = { 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 };
    readonly byte[] _iv = { 8, 7, 6, 5, 4, 3, 2, 1 };
    // define the triple des provider
    private readonly TripleDESCryptoServiceProvider _mDes = new TripleDESCryptoServiceProvider();
    // define the string handler
    private readonly UTF8Encoding _mUtf8 = new UTF8Encoding();
    // define the local property arrays
    private readonly byte[] _mKey;
    private readonly byte[] _mIv;
    /// <summary>
    /// Default constructor
    /// </summary>
    public TripleDes()
    {
        _mKey = _key;
        _mIv = _iv;
    }
    /// <summary>
    /// Parameterized constructor
    /// </summary>
    /// <param name="key"></param>
    /// <param name="iv"></param>
    public TripleDes(byte[] key, byte[] iv)
    {
        _mKey = key;
        _mIv = iv;
    }
    /// <summary>
    /// Encrypts the given byte array input
    /// </summary>
    /// <param name="input">Input value</param>
    /// <returns>Encrypted result</returns>
    public byte[] Encrypt(byte[] input)
    {
        return Transform(input, _mDes.CreateEncryptor(_mKey, _mIv));
    }
    /// <summary>
    /// Decrypts the given encrypted byte array input
    /// </summary>
    /// <param name="input">Encrypted byte array input</param>
    /// <returns>Decrypted result</returns>
    public byte[] Decrypt(byte[] input)
    {
        return Transform(input, _mDes.CreateDecryptor(_mKey, _mIv));
    }
    /// <summary>
    /// Encrypts the given string input
    /// </summary>
    /// <param name="text">Input value</param>
    /// <returns>Encrypted result</returns>
    public string Encrypt(string text)
    {
        byte[] input = _mUtf8.GetBytes(text);
        byte[] output = Transform(input, _mDes.CreateEncryptor(_mKey, _mIv));
        return Convert.ToBase64String(output);
    }
    /// <summary>
    /// Decrypts the given encrypted string input
    /// </summary>
    /// <param name="text">Encrypted string input</param>
    /// <returns>Decrypted result</returns>
    public string Decrypt(string text)
    {
        byte[] input = Convert.FromBase64String(text);
        byte[] output = Transform(input, _mDes.CreateDecryptor(_mKey, _mIv));
        return _mUtf8.GetString(output);
    }
    private static byte[] Transform(byte[] input, ICryptoTransform cryptoTransform)
    {
        // create the necessary streams
        using (MemoryStream memStream = new MemoryStream())
        {
            using (CryptoStream cryptStream = new CryptoStream(memStream, cryptoTransform, CryptoStreamMode.Write))
            {
                // transform the bytes as requested
                cryptStream.Write(input, 0, input.Length);
                cryptStream.FlushFinalBlock();
                // Read the memory stream andconvert it back into byte array
                memStream.Position = 0;
                byte[] result = memStream.ToArray();
                // close and release the streams
                memStream.Close();
                cryptStream.Close();
                // hand back the encrypted buffer
                return result;
            }
        }
    }
}