I heartily recomment tipfy
, but, as its author @moraes just said, it is its own, little, lightweight framework -- integration with others is possible (through WSGI middleware concepts), but your life is much simpler if you stick with a single framework, and django
is much richer (and, of course, much bigger and less simple -- those are two sides of the same coin;-) and very very popular.
I personally like the "very lightweight" approach of tipfy (and WSGI, and Werkzeug, on which it relies), but if you have to pick one single framework for a wide variety of uses, you could surely do much worse than going with the most popular one, that is, django (e.g. as this post suggests).