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Excuse my ignorance, but what is the high-level overview of (something like) node.js versus ZeroMQ?

+1  A: 

Node.js is a javascript vm based on V8 -- its built to be a full programming environment for asynchronous IO

ZeroMQ is a library for doing a variety of things -- message queueing over arbitrary protocols. Compatible with AMQP (message protocol) and does not have to have a broker (central routing server).

Basically totally different :-) There is even a half functional binding of ZeroMQ for node http://github.com/JustinTulloss/zeromq.node - and a more functional one for amqp in general that ry built - http://github.com/ry/node-amqp

Josh