I am betting the event handler for the button1_click event has been inadvertently removed.
Try double-clicking on the button in design time and see if it pulls you back to that same exact piece of code - or a new event handler definition.
If it's a new event handler definition - copy your code there and delete the first one.
There are other ways to manually add the event handler in the designer's code-behind - but maybe that's for a later progression.
From within VS click the "Show all files" button in solutions explorer. Grab us the code in .Designer.vb and paste it in here and we'll nail it down for you definitively.
Here's mine:
Global.Microsoft.VisualBasic.CompilerServices.DesignerGenerated()> _
Partial Class Form1
Inherits System.Windows.Forms.Form
'Form overrides dispose to clean up the component list.
_
Protected Overrides Sub Dispose(ByVal disposing As Boolean)
Try
If disposing AndAlso components IsNot Nothing Then
components.Dispose()
End If
Finally
MyBase.Dispose(disposing)
End Try
End Sub
'Required by the Windows Form Designer
Private components As System.ComponentModel.IContainer
'NOTE: The following procedure is required by the Windows Form Designer
'It can be modified using the Windows Form Designer.
'Do not modify it using the code editor.
_
Private Sub InitializeComponent()
Me.Button1 = New System.Windows.Forms.Button
Me.SuspendLayout()
'
'Button1
'
Me.Button1.Location = New System.Drawing.Point(131, 91)
Me.Button1.Name = "Button1"
Me.Button1.Size = New System.Drawing.Size(133, 50)
Me.Button1.TabIndex = 0
Me.Button1.Text = "Button1"
Me.Button1.UseVisualStyleBackColor = True
'
'Form1
'
Me.AutoScaleDimensions = New System.Drawing.SizeF(6.0!, 13.0!)
Me.AutoScaleMode = System.Windows.Forms.AutoScaleMode.Font
Me.ClientSize = New System.Drawing.Size(292, 266)
Me.Controls.Add(Me.Button1)
Me.Name = "Form1"
Me.Text = "Form1"
Me.ResumeLayout(False)
End Sub
Friend WithEvents Button1 As System.Windows.Forms.Button
End Class