Drop a pidfile somewhere (e.g. /tmp). Then you can check to see if the process is running by checking to see if the PID in the file exists. Don't forget to delete the file when you shut down cleanly, and check for it when you start up.
#/usr/bin/env python
import os
import sys
pid = str(os.getpid())
pidfile = "/tmp/mydaemon.pid"
if os.path.isfile(pidfile):
print "%s already exists, exiting" % pidfile
sys.exit()
else:
file(pidfile, 'w').write(pid)
# Do some actual work here
os.unlink(pidfile)
Then you can check to see if the process is running by checking to see if the contents of /tmp/mydaemon.pid are an existing process. Monit (mentioned above) can do this for you, or you can write a simple shell script to check it for you using the return code from ps.
ps up `cat /tmp/mydaemon.pid ` >/dev/null && echo "Running" || echo "Not running"
For extra credit, you can use the atexit module to ensure that your program cleans up its pidfile under any circumstances (when killed, exceptions raised, etc.).