This blog post describes how to prevent a PC from going to sleep using SetThreadExecutionState.  The code looks like this:
public partial class Window1 : Window
{
    private uint m_previousExecutionState;
    public Window1()
    {
        InitializeComponent();
        // Set new state to prevent system sleep (note: still allows screen saver)
        m_previousExecutionState = NativeMethods.SetThreadExecutionState(
            NativeMethods.ES_CONTINUOUS | NativeMethods.ES_SYSTEM_REQUIRED);
        if (0 == m_previousExecutionState)
        {
            MessageBox.Show("Call to SetThreadExecutionState failed unexpectedly.",
                Title, MessageBoxButton.OK, MessageBoxImage.Error);
            // No way to recover; fail gracefully
            Close();
        }
    }
    protected override void OnClosed(System.EventArgs e)
    {
        base.OnClosed(e);
        // Restore previous state
        if (0 == NativeMethods.SetThreadExecutionState(m_previousExecutionState))
        {
            // No way to recover; already exiting
        }
    }
}
internal static class NativeMethods
{
    // Import SetThreadExecutionState Win32 API and necessary flags
    [DllImport("kernel32.dll")]
    public static extern uint SetThreadExecutionState(uint esFlags);
    public const uint ES_CONTINUOUS = 0x80000000;
    public const uint ES_SYSTEM_REQUIRED = 0x00000001;
}
If you like the application described in the post, there is an updated version here.