The only optimization you can squeeze out of this is to use Assembly.GetExportedTypes() to retrieve only publicly visible types if that's the case. Other than that, there's no way to speed things up. LINQ may help with readability side of things, but not performance-wise.
You can do some short-circuiting to avoid unnecessary calls to IsAssignableFrom which is, according to Reflector, quite expensive one, by first testing whether the type in question is of required "class". That is, you're searching for classes only, there's no point in testing enums or arrays for "assignability".