On a transactional system there may be no significant benefit to putting an index on such a column (i.e. a low cardinality reference column) as the query optimiser probably won't use it. It will also generate additional disk traffic on writes to the table as the indexes have to be updated. So for low cardinality FK's on a transactional database it is usually better not to index the columns. This particularly applies to high volume systems.
Note that you may still want the FK for referential integrity and that the FK lookup on a small reference table will probably generate no I/O as the lookup table will almost always be cached.
However, you may find that you want to include the column in a composite index for some reason - perhaps to create a covering index for a commonly used query.
On a table that is frequently bulk-loaded (e.g. a data warehouse) the index write traffic will be much larger than that of the table load if you have many indexed columns. You will probably need to drop or disable the FKs and indexes for a bulk load if any indexes are present.
On a Star Schema you can get some benefit from indexing low cardinality columns, even on SQL Server. If you are doing a highly selective query (i.e. one where the query optimiser decides that the row set returned will be small) then it can do a 'star query' plan where it uses a technique known as index intersection.
Generally, query plans on a star schema should be based around a table scan of the fact table or a highly selective process that bookmarks the fact table and then returns a smaller set of rows. Index intersection is efficient for the latter type of query as the selection can be resolved before doing any I/O on the fact table.
Bitmap indexes are a real win for low cardinality columns on platforms such as Oracle that support them, but SQL Server does not. Even so, low cardinality indexes can still participate in star query plans on SQL Server.