VirtualLock by default will run out of quota in a hurry, even if you permission the user (by default the security policy setting of "Lock pages in memory" has no entries (not even admin)).
If you do configure this, you will need to set "Adjust memory quotas for a process" also.
This question is a bit ambiguous, what part of the VM space do you want to prevent from being swapped out? Heap/Stack/Module's?...?
Overall, one solution that I had used in the past, is to create a DLL with a large section which was READ + WRITE, unmoveable, you can also mark it EXECUTE and SHARED if need be, but then I would HeapCreate into that module's section, allowing me to use it as a heap.
You can look up the exact bit's to set here, IMAGE_SCN_MEM_NOT_PAGED
looks like it would do the trick.
If you go through the process of marking all of your module's and sections with this bit, the Windows module loader will not charge a articular user quota or require policy settings be modified on each system you deploy your code. You will need to code in a special shim to provide access to the HEAP's you create into these NON_PAGEABLE dll's also.
It is a bit of work but it worked well for me in the past, I had the added requirement to share memory to multiple processes, which was based at the same address.
I would think the easiest thing to try would be to disable your page file entirely. But before this, if your using Vista/2008+ OS's, the swapping you see may be due to superfetch, which could be proactively "tuning" your system with the assumption that in the near future you need to use one application or another. Some other easy tasks would be to stop unused services like search, which could be indexing huge amounts of files, also you should go into your "task scheduler", which configures system tasks, by default there are a few dozen on most systems with default action's that will transmit all Dr. Watson dump's to MS, defrag your drive and a number of other possibly exceedingly memory intensive type operations.
You could reply with a bit more detail to get some better answers... but one other suggestion would be to simply purchase a large solid state drive and use that exclusively for swap, beware that these degrade over time in overall performance an size due to bad block mappings that are common with all existing SSD technologies.
I recently came across a codeplex project called "non-paged clr host", from their page:
Implementation From an implementation perspective, the
non-paged CLR host uses the
SetProcessWorkingSetSize,
SetProcessWorkingSetSizeEx (on Windows
Server 2003 and above) and VirtualLock
APIs to ensure that memory allocated
by it is locked into physical memory.
Note that using the above APIs does
not guarantee with absolute certainty
that no paging will occur; instead, it
minimizes the odds of it occurring to
very exceptional scenarios. In some
load tests we have conducted, even
when the system as a whole was hogged
by lack of physical memory, no page
faults were observed in the process
using the non-paged CLR host.