You can't really rely on external processes. All 'OS' based solutions I've seen failed to deliver in the real world: a database is way more than just the data, primarily because of the backup/restore strategy, the high availability strategy, the disaster recoverability strategy and all the other 'ities' you pay for in your SQL Server license. An OS scheduler based will be an external component completely unaware and unintegrated with any of them. Ie. you cannot back/restore your schedule with your data, it will not fail over with your database, you cannot ship it to a remote disaster recovery site through your SQL data shipping channel.
If you have Agent (ie. not Express edition) then use Agent. Has a long history of use and the know how around it is significant. The only problem with Agent is its dependence on msdb that makes it disconnect from the application database and thus does not play well with mirroring based availability and recoverability solutions.
For Express editions (ie. no Agent) the best option is to roll your own scheduler based on conversation timers (at least in SQL 2k5 and forward). You use conversations to chedule yourself messages at the desired moment and rely on activated procedures to run the tasks. They are transactional and integrated with your database, so you can rely on them being there after a restore and after a mirroring or clustering fail over. Unfortunately the know how around how to use them is fairly skim, I have several articles about the subject on my site rusanu.com. I've seen systems replicating a fair amount of Agent API on Express relying entirely on conversation timers.