This is a bit like beating a dead horse, but I'll have a go at it, sure.
I think there could be two basic approaches to this:
1.
Using ajax (and, basically,
javascript) to enhance the experience
of the users, while making sure, that
all of the application's features
work without javascript.
When I am
following this principle, I develop the
interface in two phases - first
without considering javascript at all
(say, using a framework, that doesn't
know about javascript) and then
augment certain workflows by adding
ajax-y validation (don't like pure js
validation, sorry) and so on.
This means, if the user has javascript disabled, your app shall in no way break or become unusable for him.
2.
Using javascript to its fullest, "no javascript - no go" style. If javascript is not available, the user will not be able to use your application at all. It is important to note, that, in my opinion, there is no middle ground, - if you are trying to be in both worlds at once, you are doing too much extra work. Removing the constraints of supporting no-javascript users, obviously adds more opportunities to create a richer user experience. And it makes creating that experience much easier.