First off, I am not a DBA, but I do work in an environment where DBAs do tune/make changes in the production database from time to time in ways that do not cause the need for an application rebuild/redeployment. Usually these changes consist of reworking indexes, changing procs, and sometimes changing the table structure in minor ways (usually abstracted from the app via procs).
Obviously, a team should strive to catch performance problems with NHibernate before they get into production using things like NHProf, SQL Profiler, and load tests. That being said, are there certain strategies that can be used to allow some amount of tweaking once the code is built and out running in production? Using stored procedures 100% of the time seems like it would allow the most flexibility for the DBA's, but obviously that would really kill the efficiency of NHibernate. From what I've read, updatable views (in SQL Server) don't really work that well with NHibernate either (this may-or-may-not be true).
I've read quite a bit about NHibernate and experimented with it over the years, but I have never put it into practice in a production environment. I have yet to come across a set of "best practices" to allow for maximum tweaking once deployed.
As an NHibernate user, how are you and your team dealing with issues if they arise in production? My production environment is made up of ASP.NET apps and SQL server, but I don't think the answers need to be restricted to that platform.