Ordinarily it indicates a 404 error or some other error, but here you have a 200 status. Use the plus button to expand and look at the response headers. What do they say?
Edit: I checked the Firebug source. It definitely means their was a response header in the 400 or 500 range.
Why do you have a 200 OK header, also? I couldn't tell you. I can say that it's based on more than just the response headers looking at the logic in FB. However, I'm not that familiar with it (first time that I've looked at firebug's source).
If you're very curious about the red AND the 200 OK, check out what you have under the plus button. If that doesn't answer your question (do you have a page but maybe it's a 404 page?), fire up a packet sniffer to see in full detail what happens after the initial error header.