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We have MySQL 4 master masters and several read slaves of each master running MySQL. We roll with InnoDB, should we be looking towards XtraDB?

We have to be able to average many comments a second which typically trigger 10 inserts and 100 reads.

+2  A: 

Either will work.

There are both performance an usability enhancements in XtraDB you will be able to benefit from: http://www.percona.com/docs/wiki/percona-xtradb:features:start

It's best not to think of XtraDB as more of a series of after market enhancements than a complete fork - as it still re-bases itself against newer MySQL releases.

Morgan Tocker