Meta Data was extremely useful for me for purposes of typing. I'm talking not just about type hints, but about complete custom type system. Simplest example - overloading of print-method for structs (or any other var):
(defstruct my-struct :foo :bar :baz)
(defn make-my-struct [foo bar baz]
(with-meta (struct-map my-struct :foo foo :bar baz :baz baz)
{:type ::my-struct}))
(defmethod print-method
[my-struct writer]
(print-method ...))
In general, together with Clojure validation capabilities it may increase safety and, at the same time, flexibility of your code very very much (through it will take you some more time do actual coding).
For more ideas on typing see types-api.