Are you talking internal to the enterprise, or a corporate grade customer facing web page?
If you're talking internal to the enterprise, simple and functional is usually preferred over anything fancy (the primary purpose is to serve information to the employees...doesn't really need to look pretty). Lay out the site using the corporate color scheme, make it simple and easy to use...and you should have a winner.
If you're talking a public facing external site, things get much more difficult. There are things like language tone, copy, asset consistency, etc. to worry about. If you're more familiar with the back end (like myself) it's usually a much better idea to get some help from a real designer (or if the company is large enough, a marketing/design firm). You'll spend much less time fighting yourself and learn a lot in the process.