JavaScript, the language, can be as multithreaded as you want, but browser embeddings of the javascript engine only runs one callback (onload, onfocus, <script>, etc...) at a time (per tab, presumably). William's suggestion of using a Mutex for changes between registering and receiving a callback should not be taken too literally because of this, as you wouldn't want to block in the intervening callback since the callback that will unlock it will be blocked behind the current callback! (Wow, English sucks for talking about threading.) In this case, you probably want to do something along the lines of redispatching the current event if a flag is set, either literally or with the likes of setTimeout().
If you are using a different embedding of JS, and that executes multiple threads at once, it can get a bit more dicey, but due to the way JS can use callbacks so easily and locks objects on property access explicit locking is not nearly as necessary. However, I would be surprised if an embedding designed for general code (eg, game scripting) that used multi threading didn't also give some explicit locking primitives as well.
Sorry for the wall of text!