We have our own ORM we use here, and provide strongly typed wrappers for all of our db tables. We also allow weakly typed ad-hoc SQL to be executed, but these queries still go through the same class for getting values out of a data reader.
In tweaking that class to work with Oracle, we've come across an interesting question. Is it better to use DBNull.Value, or null? Are there any benefits to using DBNull.Value? It seems more "correct" to use null, since we've separated ourselves from the DB world, but there are implications (you can't just blindly ToString() when a value is null for example) so its definitely something we need to make a conscious decision about.