I believe you have the answer you need to profile the queries. However, this is the easiest part of performance tuning. Once you know it is the queries and not the network or the app, how do you find and fix the problem?
Performance tuning is a complex thing. But there some places to look at first. You say you are returning lots of data? Are you returning more data than you need? Are you really returning only the columns and records you need? Returning 100 columns by using select * can be much slower than returning the 5 columns you are actually using.
Are your indexes and statistics up-to-date? Look up how to update statisistcs and re-index in BOL if you haven't done this in a awhile. Do you have indexes on all the join fields? How about the fields in the where clause.
Have you used a cursor? Have you used subqueries? How about union-if you are using it can it be changed to union all?
Are your queries sargable (google if unfamiliar with the term.)
Are you using distinct when you could use group by?
Are you getting locks?
There are many other things to look at these are just a starting place.