I've got a user that is not able to launch our ClickOnce application (there are thousands of users that can just fine). They are not receiving any errors nor does the ClickOnce installation dialog display. The only thing that happens when they click the button to launch it is a progress bar shows up in the bottom of the screen saying that it is downloading the url.
The application is .Net 2.0 (I don't reference any of the 3.x assemblies). The user has Windows Vista and IE8. I checked the ClickOnce cache and it is empty (no applications at all). What else should I look at?