We have a user who is having problems with a ASP.NET app. The user hasn't been available to gather many details, but at this point our best guess is that the PostBack is not occurring. Something is going wrong between when the user clicks the LinkButton and when the HTTP Request is supposed to be made.
(User does have JS enabled)
Beyond solving the immediate problem, it might be helpful for posterity to assemble the canonical list of things that can break PostBack behavior of ASP.NET controls.