Before sounding so condescending, you may want to read up on the modern user base. Netbooks. PDAs. Smartphones. Smartbooks (you do know what those are, being very sophisticated, right?). Programmers who have their screen in portrait orientaton. People who stack their windows side by side. Kiosks.
UPDATE As per conversation with John, I edited the question to change the tenor a bit to reflect his original intent. However, the original paragraph that I wrote is still true- I haven't seen the latest statistics but the days of "90% of users have AxB resultion/window size on their browser" are probably forever gone, what with wide screen laptops and mobile devices. Makes life more exciting for UI designers :)
Having said that, to develop a really usable web site, you need to couple flowing layout with, ideally, ability to use portlets and portal framework (think My Yahoo), so people can choose the page layout most comfortable for them.