+3  A: 

I can tell you first hand Microsoft knows about the IE problem(KB 2000262) with UpdatePanels. Its a DOM parser issue. I had a site that ran fine up until a certain page content size and then IE(all versions) had a fit. FF and other browsers handled the same pages with ease.

Things I did to make my pages faster:

  • Use UpdateMode=Conditional wherever possible
  • Implement the KB 2000262 fix

UpdatePanel Async Postsback slow in IE…Part 3

rick schott