.c : c file (where the real action is, in general)
.h : header file (to be included with a preprocessor #include
directive). Contains stuff that is normally deemed to be shared with other parts of your code, like function prototypes, #define'd stuff, extern declaration for global variables (oh, the horror) and the like.
Technically, you could put everything in a single file. A whole C program. million of lines. But we humans tend to organize things. So you create different C files, each one containing particular functions. That's all nice and clean. Then suddenly you realize that a declaration you have into a given C file should exist also in another C file. So you would duplicate them. The best is therefore to extract the declaration and put it into a common file, which is the .h
For example, in the cs50.h you find what are called "forward declarations" of your functions.
A forward declaration is a quick way to tell the compiler how a function should be called (e.g. what input params) and what it returns, so it can perform proper checking (for example if you call a function with the wrong number of parameters, it will complain).
Another example. Suppose you write a .c file containing a function performing regular expression matching. You want your function to accept the regular expression, the string to match, and a parameter that tells if the comparison has to be case insensitive.
in the .c you will therefore put
bool matches(string regexp, string s, int flags) { the code }
Now, assume you want to pass the following flags:
0: if the search is case sensitive
1: if the search is case insensitive
And you want to keep yourself open to new flags, so you did not put a boolean.
playing with numbers is hard, so you define useful names for these flags
#define MATCH_CASE_SENSITIVE 0
#define MATCH_CASE_INSENSITIVE 1
This info goes into the .h, because if any program wants to use these labels, it has no way of knowing them unless you include the info. Of course you can put them in the .c, but then you would have to include the .c code (whole!) which is a waste of time and a source of trouble.