I don't think you can delete from multiple tables at once (though I'm not certain).
It sounds to me, however, that you would be best to achieve this effect with a relationship that cascades deletes. If you did this you would be able to delete the record from one table and the records in the other would be automatically deleted.
As an example, say the two tables represent a customer, and the customer's orders. If you setup the relationship to cascade deletes, you could simply delete record in the customer table, and the orders would get deleted automatically.
See the MSDN doc on cascading referential integrity constraints.