The SerialPort class has an Open method, which will throw a few exceptions.
The reference above contains detailed examples.
See also, the IsOpen property.
A simple test:
using System;
using System.IO.Ports;
using System.Collections.Generic;
using System.Text;
namespace SerPort1
{
class Program
{
static private SerialPort MyPort;
static void Main(string[] args)
{
MyPort = new SerialPort("COM1");
OpenMyPort();
Console.WriteLine("BaudRate {0}", MyPort.BaudRate);
OpenMyPort();
MyPort.Close();
Console.ReadLine();
}
private static void OpenMyPort()
{
try
{
MyPort.Open();
}
catch (Exception ex)
{
Console.WriteLine("Error opening my port: {0}", ex.Message);
}
}
}
}