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i want to design computer based measurement system to measure different low level voltages the net search suggested for ADC and serial port programming if someone can help me how to program serial port or if any other mean to creat the measurement system

A: 

This question is probably a little beyond the scope of SuperUser since it requires a combination of software and hardware design which would be hard to describe.

But there's plenty of references on the 'Net. Here's one which closely follows what you describe.

pavium