You could use ApplicationCommands.New for this since it already provides that functionality. The default WPF Command Model is pretty cool. Even if you decide not to use the default commanding model, that second link should show you how to hook up the input gestures you need.
EDIT: Here is a sample implementation...
<Window.CommandBindings>
<CommandBinding Command="ApplicationCommands.New"
CanExecute="NewApplicationCommand_CanExecute"
Executed="NewApplicationCommand_Executed" />
</Window.CommandBindings>
<Grid>
<Menu>
<MenuItem Header="_File">
<MenuItem Command="ApplicationCommands.New" Header="_New Project" />
</MenuItem>
</Menu>
</Grid>
And the code behind...
private void NewApplicationCommand_CanExecute(object sender, CanExecuteRoutedEventArgs e)
{
// Whatever logic you use to determine whether or not your
// command is enabled. I'm setting it to true for now so
// the command will always be enabled.
e.CanExecute = true;
}
private void NewApplicationCommand_Executed(object sender, ExecutedRoutedEventArgs e)
{
Console.WriteLine("New command executed");
}