Answered in the forums: http://groups.google.com/group/httpfiddler/browse_thread/thread/8075b029d3b66720
While your application can use FiddlerCore to return
responses of your choosing, the current public FiddlerCore bits don't
have the ability to read .SAZ files. Fiddler depends on Xceed's Zip
libraries for opening SAZ files, but those libraries are not free (MS
itself has a site license, which is how Fiddler itself may use
them).
A future version of FiddlerCore will likely use one of the opensource
ZIP libraries from CodePlex, at which point FiddlerCore will be able
to open and process a SAZ File, but you'll still need to write the
code that actually matches a given request to a previously loaded
response yourself-- the "AutoResponder" code is a part of Fiddler, not
FiddlerCore.