I was recently asked to speed up a C#/ASP.NET/SQL Server business app website. Since I just started, I don't know too much about the internals. So where do I start? Sight unseen, what is the single most important thing affecting performance on a system like this? Database tuning? Hardware? Individual page optimization? What is the first thing you'd look at?
EDIT: After I actually do the work, I'll come back and post the answer. ;)
EDIT again: "Profile" is currently the most-voted answer, and I agree that that is clearly what one should do. But I was looking for guesses/experience as to what the profiling results would show, so I don't think that answer counts...