Probably you would want to implement an HttpModule. Otherwise you are fighting with all the other HttpHandlers that are vying for the request.
This should get you started....
You can decide where in the request lifecycle you want to perform your check and react. See this article for some background
using System;
using System.IO;
using System.Web;
namespace RequestFilterModuleTest
{
public class RequestFilterModule : IHttpModule
{
#region Implementation of IHttpModule
/// <summary>
/// Initializes a module and prepares it to handle requests.
/// </summary>
/// <param name="context">
/// An <see cref="T:System.Web.HttpApplication"/> that provides access to the methods,
/// properties, and events common to all application objects within an ASP.NET application
/// </param>
public void Init(HttpApplication context)
{
context.BeginRequest += ContextBeginRequest;
}
/// <summary>
/// Disposes of the resources (other than memory) used by the module that implements <see cref="T:System.Web.IHttpModule"/>.
/// </summary>
public void Dispose()
{
}
private static void ContextBeginRequest(object sender, EventArgs e)
{
var context = (HttpApplication) sender;
// this is the file in question
string requestPhysicalPath = context.Request.PhysicalPath;
if (File.Exists(requestPhysicalPath))
{
return;
}
// file does not exist. do something interesting here.....
}
#endregion
}
}
<?xml version="1.0"?>
<configuration>
...............................
<system.web>
...........................
<httpModules>
<add name="RequestFilterModule" type="RequestFilterModuleTest.RequestFilterModule"/>
<add name="ScriptModule" type="System.Web.Handlers.ScriptModule, System.Web.Extensions, Version=3.5.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35"/>
</httpModules>
</system.web>
...................
</configuration>