This was inspired by a question I asked recently regarding design time behaviour in my WPF app. (http://stackoverflow.com/questions/2290499/cant-databind-at-design-time-in-wpf-using-mvvm-viewmodel-property-never-gets-c)
The net result of that is that my design time DataContext/ViewModel works perfectly in Blend, but doesn't show up in Visual Studio 2008. I've decided not to look further into it as Blend support is all I really need, but this surprised me as I had been working under the assumption that Blend and VS would have similar if not identical WPF designers.
So what are the differences? Any other gotchas anyone is aware of? All info welcomed :)