UNIQUE will locate the verbatim short_title using the underlying index.
If you need a word match (as opposed to verbatim match), use FULLTEXT index.
Also note that by default the B-Tree indexes in MyISAM against the VARCHAR columns are subject to key compression. This can slow down the searches for the titles closer to the end of the alphabet:
Finally, the VARCHAR keys tend to be large in size.
For the fastest verbatim searches, you should store a MD5 hash of the title in a BINARY(16) column, create a UNIQUE index over it (disabling the key compression) and search for the hash.