I will answer only one answer, from prior experience - take a look at this middle-ware that is employed by big companies here - middle-ware has one purpose - to glue dis-connected systems (written in disparate languages) together so that they can interact with one another and streamline the business process - Entera as I have had experience with, creates a middle layer in which the unix box using processes written in C, interact with the mainframe system (DB2, COBOL) via a front-end written in PowerBuilder (I am not naming the company!).
From the description I have given, Entera is a middle-ware which hosts a number of things - smooth integration of the flow of data regardless of the endian format, ability for different languages to talk to the middle-ware broker (a broker is a CORBA or DCE like process, that conforms to 'The Open Group) that listens on a particular port) and is specified by an IDL which makes a process appear to be local - if you understand the terminology used in Remoting under Microsoft's .NET Framework, you are not far off the mark! The middle-ware generates stubs which are linked at compile-time and manages the creation of the process, hosting it off a port, multi-threading at run-time, and also, the modern front-ends (such as .NET, Java, PowerBuilder even the unspeakable VB6...ok...VB.NET for the purists out there) can interact by opening a connection to the specified port on a particular IP address, and using the stubs generated, can interact with it directly.
Obviously, from what was described you can see how the legacy systems can have new life breathed into it and thus scalability of the process, the major downside of this is the cost factor which can run into thousdands of dollars. Big companies who uses mainframes as their back-end processing systems for billing/invoicing, who generate a huge revenue can obviously afford such an expensive product - to them it would seem like throwing pennies into a pool of water...because of the use of middle-ware which prolongs the business process, and breathe new life into it, can extend the business by a good number of years into the future without worrying about 'legacy' tag attached to it.
Incidentally, I carried this out as part of my thesis for my BSc. in Information Systems which covered this commercial front-end. There was an open source version of the middle-ware available on sourceforge called FreeDCE, but development efforts have declined or stopped.
Edit:
@cocotwo: That is exactly what middle-ware does as you said it is a plumbing tool...message oriented middle-ware is not really heard of AFAIK because I would imagine, the processes (functions) would need to be called as if they are locally visible within the application domain of the front-end to make it easy to interact with.
Using messages may have its advantages over RPC calls in that the messages are queued in a safe-holding area in the event that a network disconnection occurs - there may be some data caching going on within that aspect to allow the front-end to continue regardless...it would be useful in the instances of 'updating a status of a particular billing/invoice number' - a one-way write-data to the back-end via the middle-ware.
Ok, big companies would have advanced systems infrastructure in that technicians are constantly around the clock to ensure a smooth delivery of data-flow so that would have to be factored in. The company that I worked with had IBM Global Support contract to fulfill in order to ensure a maximum uptime 99% with 6 nine's after the decimal point...with hot-swapping/balanced-clusters/mirroring systems in place...
Whereas with RPC, if the disconnection occurs, the front-end would have to be restarted or would have to handle the disconnection event. It really depends if the message-queueing middle-ware handles each message in real-time and pass back results to the front-end immediately...
This is where each (Message-queueing and RPC related middle-ware) have their strengths and weaknesses...and also the cost mitigation factor such as support, maximum up-time, development efforts and training - that's a biggie here as middle-ware are really proprietary (despite following the 'The Open Group' layout/standards) and complex to setup and to glue the whole thing together via scripts.
Hope this helps,
Best regards,
Tom.