@Debilski - I wrote something similar to your active * code for the acronyms in my thesis. I activated < and then \def<#1> to print the acronym, as well as the expansion if it's the first time it's encountered. I also went a bit off the deep end by allowing defining the expansions in-line and using the .aux files to send the expansions "back in time" if they're used before they're declared, or to report errors if an acronym is never declared.
Overall, it seemed like it would be a good idea at the time - I rarely needed < to be catcode 12 in my actual text (since all my macros were in a separate .sty file), and I made it behave in math mode, so I couldn't foresee any difficulties. But boy was it brittle... I don't know how many times I accidentally broke my build by changing something seemingly unrelated. So all that to say, be very careful activating characters that are even remotely commonly-used.
On the other hand, with XeTeX and higher unicode characters, it's probably a lot safer, and there are generally easy ways to type these extra characters, such as making a multi (or compose) key (I usually map either numlock or one of the windows keys to this), so that e.g. multi-!-! produces ¡). Or if you're running in emacs, you can use C-\ to switch into TeX input mode briefly to insert unicode by typing the TeX command for it (though this is a pain for actually typing TeX documents, since it intercepts your actual \'s, and please please don't try defining your own escape character!)