This is a bug caused by IE8 users, you can read about it here: http://blogs.msdn.com/ieinternals/archive/2009/07/27/Bugs-in-the-IE8-Lookahead-Downloader.aspx
The basics are that when IE8 processes the page, it sometimes just leaves 4kb out of it, and if your <script src="ScriptResource.axd?....
started and gets truncated, when the page is rejoined with 4k missing, up until the matching quote to close the src=""
is used, resulting in a very strange request to your server.
Update: It's been fixed now with KB980182 (4/1/2010)
Nick Craver
2010-04-03 16:02:33