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I have a ClickOnce app that calls WebServices on the server (standard ASMX style, not WCF). Occasionally, the users get this error:

System.Reflection.TargetInvocationException: An exception occurred during the operation, making the result invalid. Check InnerException for exception details.

System.Net.WebException: Unable to connect to the remote server System.Net.Sockets.SocketException: A connect request was made on an already connected socket

This occurs fairly rarely (10-20 times a day out of nearly a million calls), but still enough that users complain about it once in a while.

The server is a standard Windows 2003 R2 with IIS.

What could be the issue here?