Interesting. I think your best bet is going to be to use the FD that you have to write a temporary file and then exec it using a normal exec call.
You can use mkstemp
to make a guaranteed unique file name. Then read the content from your file descriptor and dump it to the temp file. Then use the name given to you by mkstemp in an exec call.
If you don't for some reason want to write a new file then I think your only other option will be to manually parse the exe file image, load it properly in memory, and then call it's main() function. That's duplicating a lot of functionality that already exists in the OS, and I don't think you want to do it. It will be hard to get right, and does not seem to be worth the effort.