I've noticed that if I build my WPF application for Any CPU/x64, it takes MUCH longer to start (on the order of about 20 seconds) or to load new controls than it does if started on x86 (in release & debug modes, inside or outside of VS). This occurs with even the simplest WPF apps. The problem is discussed in this MSDN thread, but no answer was provided there. This happens only with .NET 4.0 -- in 3.5 SP1, x64 was just as fast as x86. Interestingly, Microsoft seems to know about this problem since the default for a new WPF project in VS2010 is x86.
Is this a real bug or am I just doing it wrong?
EDIT: Possibly related to this: http://stackoverflow.com/questions/2788215/slow-databinding-setup-time-in-c-net-4-0. I'm using data binding heavily.