It's a relatively new technology, so I'm not sure if it's exactly mature. I'm sure it will change quite a bit over the next several years, perhaps merging with other frameworks to better support IoC. That said, MS has a pretty good history of preserving backwards compatibility, so now that MEF is actually part of the Framework, I would consider the public interfaces stable.
That said, MEF might not actually be the right solution for your project. It depends on your extensibility needs and how large is 'large'. If you want to support true extensibility, including the possibility for third-party plugins, it has an enormous impact on your design responsibilities. It's much harder to make changes to the infrastructure as you now need to maintain very stable public interfaces. If you're really only after the IoC features, you're probably better off with a true IoC framework, which more clearly limits your design responsibility to support of your internal dependencies. If you're betting the future of the company, this is the bigger question, in my mind.