Use the :eq selector:
$("#Grid td:first-child").click(function() {
var value = $(this).closest('tr').find('td:eq(2)').text(); // for third column
alert(value);
var value = $(this).closest('tr').find('td:eq(3)').text(); // for fourth column
alert(value);
});
That will alert value of 3rd and 4rth TD/column when first td of element with id Grid (td:first-child) is clicked.
If however, you want an array of values of TDs, use the map and get methods like this:
$("#Grid td:first-child").click(function() {
var value_array = $(this).closest('tr').find('td').map(function(){
return $(this).text();
}).get();
});
Now value_array will contains text for found TDs eg:
value_array[0] // first
value_array[1] // second
value_array[2] // third