Usually it's enough to create a stylesheet that looks well in normal browsers, and then make a IE-only supplemental stylesheet that fixes the incompatibilities and include it through conditional comments (although IE8+ is kind of OK and IE7 usually works):
<!--[if IE]>
<link rel="stylesheet" href="/ie_sheet.css" type="text/css">
<![endif]-->
Since IE6 is a horrible monster from the dawn of time, which needs its own specific hacks, you can include a different stylesheet for IE6 (and lower) and IE7 (and higher; not really needed most of the time):
<!--[if lte IE 6]>
<link rel="stylesheet" href="/ie6_sheet.css" type="text/css">
<![endif]-->
<!--[if gt IE 6]>
<link rel="stylesheet" href="/ie_newer_sheet.css" type="text/css">
<![endif]-->
Other browsers parse these as HTML comments and ignore them.
See also: a more detailed discussion of conditional comments.