None of us except people who work very closely with the OS and the App store policy in Apple would know whether it is "safe" to develop apps using this technology. Apple can say no anytime in the future, but we don't know. What we know is that all the compiled code has to be in C, C++, or Obj-C. However there's one catch: In some cases you can run interpreted languages.
If I were you, I'd go with Objective-C. We know that Apple supports it fully, it's been in there for almost 20 years. It's not that hard to learn since you know C#. I came from C++/C and it took me about a month or so to learn half of the frameworks. There are many other frameworks which I didn't learn because they're not applicable in my apps (such as accelerators, GPS, OpenGL ES, etc). You probably can get away with this too.
Once again, there's also another way: build it with HTML5. However that way you'd have to consider what your app'll do when it's opened with Safari desktop, Firefox, IE, etc.